那顺布和教授，研究生导师

学科：生殖生物学、表观遗传学

电话：0471-4992435

邮箱：bnashun@imu.edu.cn

通信地址：内蒙古呼和浩特市昭君路24号，内蒙古大学生命科学学院（南校区），邮编010070

简要介绍：

那顺布和博士于2016年以“内蒙古大学高层次引进人才”从英国引进到内蒙古大学生命科学学院工作。欧盟“玛丽·居里”研究员，引进当年晋级中央组织部“青年千人计划”最后面试选拔阶段。长期从事卵母细胞和胚胎发育的表观遗传学机理研究。系统阐明了组蛋白H2A和H3变异体对受精和体细胞克隆过程中基因组重编程的作用机理。揭示了蛋白H3.3及其分子伴侣Hira 调控卵母细胞发育和受精的分子机制。主要利用单细胞或少量细胞的全基因组测序技术，结合生物信息学方法系统研究哺乳动物卵母细胞和胚胎发育的表观遗传学机理。在“Molecular Cell”, “EMBO J”, “Development”， “Nature Cell Biology”等知名期刊发表数篇论文，总他引次数350余次。

研究领域

➢   哺乳动物卵母细胞和胚胎发育

➢   组蛋白变异体及其分子伴侣对重编程的作用

➢   单细胞或少量细胞的全基因组测序研究

学习和工作经历

1999.9-2003.7，内蒙古大学生命科学学院，生物基地专业，学士

2003.7-2006.7，北京师范大学细胞生物学研究所，细胞生物学，硕士

2006.9-2007.8，东北师范大学留日预校，国家公派日本语培训

2007.10-2011.9，日本东京大学研究生院，生殖生物学与表观遗传学，博士

2012.3-2013.8，Medical Research Council - Clinical Sciences Centre (MRC-CSC), Career Development Fellow

2013.9-2015.8, Imperial College London, Faculty of Medicine, “Marie Curie” Fellow

2015.9-2016.11, Medical Research Council-London Institute of Medical Sciences (MRC-LMS), Postdoctoral Research Fellow

2016.7-至今，内蒙古大学生命科学学院 副教授、教授

代表性学术论文

1. Amouroux R, Nashun B, Shirane K, Nakagawa S, Hill PW, D’Souza Z, Nakayama M, Matsuda M, Turp A, Ndjetehe E, Encheva V, Kudo N, Koseki H, Sasaki H and Hajkova P. (2016). “De novo DNA methylation drives 5hmC accumulation in mouse zygotes”. Nature Cell Biology, 2016, 18(2):225-233.

2. Nashun B, Hill PW, Smallwood SA, Dharmalingam G, Amouroux R, Clark SJ, Sharma V, Ndjetehe E, Pelczar P, Festenstein RJ, Kelsey G, Hajkova P. “Continuous histone replacement by Hira is essential for normal transcriptional regulation and de novo DNA methylation during mouse oogenesis.” Mol Cell. 2015; 60(4):611-625.

3. Nashun B*, Hill PW and Hajkova P. “Reprogramming of cell fate: epigenetic memory and the erasure of memories past.” EMBO J.2015, 34:1296-1308. *co-first author

4. Leitch HG, McEwen KR, Turp A, Encheva V, Carroll T, Grabole N, Mansfield W, Nashun B, Knezovich JG, Smith A, Surani MA, Hajkova P. “Naive pluripotency is associated with global DNA hypomethylation.” Nat Struct Mol Biol., 2013, 20, 311-316.

5. Nashun B*., Akiyama T*., Suzuki M and Aoki F. “Dramatic replacement of histone variants during genome remodeling in nuclear-transferred embryos.”  Epigenetics, 2011, 6(12), 1489-1497. *co-first author

6.Nashun B., Yukawa M., Liu H., Akiyama T., Aoki F. “Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice.”  Development, 2010, 137(22), 3785-3794.

7. Nashun B., Aoki F. “The preferential incorporation of H2A.X into chromatin in early preimplantation embryos involves its C-terminal domain.”  Developmental Biology, 2010, 344(1), 463-463.