左永春，1982年4月出生，生物信息学博士，教授，博士生导师。

主要采用计算生物学和生物信息学方法，针对哺乳动物早期胚胎发育和体细胞重编程分子机制，和生物序列的DNA/蛋白质功能分类预测方面展开大数据多组学研究，包括早期胚胎发育和体细胞重编程分子信息数据库的开发，细胞重编程关键分子途径的大数据生物信息学解析，以及基因组DNA和蛋白质序列的预测分类模型构建等。先后在生物信息学专业领域的相关学科杂志Bioinformatics、Brief Bioinform、GigaScience等SCI学术期刊上发表学术论文50多篇， ESI高被引论文多篇，获批国家发明专利多项。

目前作为主持人先后承担国家自然基金和其它省部级基金项目10多项，2008、2010、2014获全国生物信息学与系统生物学学术大会优秀奖，2010年获国家宝钢教育基金特等奖,2014年获内蒙古自治区优秀博士学位论文，2017年获内蒙古自治区杰出青年培育基金，同时入选内蒙古自治区青年科技英才和内蒙古大学“国家杰出（优秀）青年科学基金”首批培育人才。2010年组织举办内蒙古自治区首届生物信息学研究生论坛学术会议，2017年和2018年连续2次联合举办“计算表观遗传学大数据”前沿学术论坛。

联系方式：0471-5227683，   Email：yczuo@imu.edu.cn、

小组网站：http://bioinfor.imu.edu.cn  

研究领域：生物信息学，计算生物学

 研究内容：
 (1)  发育和重编程大数据生命组学方面：通过将目前公共数据平台的高通量基因组、转录组、表观组等多组学数据与本实验室内部产生的数据进行整合分析，利用大数据生物信息学方法系统分析哺乳动物早期胚胎发育和体细胞多种重编程的分子差异，筛选并探究一系列引起细胞编程和重编程阻滞的分子调控通路（Oncotarget, 2016 7(45):  74120-74131；Oncotarget, 2017），首次揭示了异种克隆动物胚胎发育受阻的关键转录因子调控网络（BMC Genomics. 2016 17:188; Brief Bioinform. 2017 18(4):712-721），最近基于蛋白质家族序列保守性和选择进化压力，解析了DNA去甲基化关键蛋白TET家族功能发挥的序列基础（Brief Bioinform. 2018 bby053）。 
(2) 计算生物学方面：自2009年起，较早地发展了基于DNA物理化学作为特征参数建立原核生物和植物启动子基因组区域预测模型的方法(Prog Biochem Biophys 2009 36(7): 863-871; Physica A 2010  389(19) 4217–4223; Genomics 2011 97(3): 112-120)，首次将离散增量算法与K紧邻算法有机结合，先后提出了K 近邻平均离散增量算法K-MID(Amino Acids 2010, 38:859–867)和K 近邻最小离散增量算法KNN-ID(Amino Acids. 2013, 44(2):573-80; Mol Biosyst. 2015 11(3):950-7)，发展了基于蛋白质序列氨基酸约化(Reduced Amino Acids)用于蛋白质的功能分类的方法(Peptides. 2009, 30(10)1788–1793; Plos one, 2015 10(12):e0145541)，成功搭建了大数据蛋白质序列氨基酸约化与特征提取数据分析平台(Bioinformatics. 2017, 33(1):122-124)。 
(3)  功能基因组学方面：开发了一套基于生物信息学方法的外源基因密码子优化和组织特异性表达调控元件改造方法，优化的人源化亚麻脂肪酸脱氢酶基因FAD3已经成功用于动物基因修饰育种(国家发明专利号：ZL201310344833.5)。通过筛选出具有组织特异的启动子和增强子序列转录因子结合位点调控Motif，该算法已成功构建了MRF4人工设计肌肉特异性表达启动子调控元件(国家发明专利号：ZL201410123506.1)，已在具有经济价值的动物基因编辑育种上进行了试验，效果明显。  

主持的相关项目： 
 国家自然科学基金，  2018-2020， 国家基金委  主持
 内蒙古自治区高等学校“青年科技英才”支持计划，2018-2020，内蒙古自治区教育厅 主持
 内蒙古自治区"杰出青年"培育基金，  2017-2019， 内蒙古自治区科技厅  主持
 国家自然科学基金，  2016-2019， 国家基金委  主持
 国家自然科学基金，  2015-2015， 国家基金委  主持
 高等学校博士点项科研基金，   2014-2016， 教育部  主持 
 内蒙古自治区自然科学基金，   2013-2015， 内蒙古自治区科技厅  主持

已发表的论文(#第一作者, *通讯作者)：
2018:
(57).  Rongsong Luo, Chunling Bai, Lei Yang, Zhong Zheng, Guanghua Su, Guangqi Gao, Zhuying Wei, Yongchun Zuo*, Guangpeng Li, DNA methylation subpatterns at distinct regulatory regions in human early embryos, Open Biol. 2018, 8: 180131. (2017 IF: 3.286).  
(56).  Wen Jin, Qianzhong Li, Yongchun Zuo, Yanni Cao, Luqiang Zhang, Rui Hou, Wenxia Su, The relationship between DNA methylation in key region and the differential expressions of genes in human breast tumor tissue, DNA and Cell Biology, 2018 Accepted. (2017 IF: 2.634).  
(55).  Guangqi Gao  Meng Xu  Chunling Bai  Yulan Yang  Guangpeng Li  Junyang Xu Zhuying Wei  Jiumeng Min  Guanghua Su  Xianqiang Zhou  Jun Guo  Yu Hao Guiping Zhang  Xukui Yang  Xiaomin Xu  Randall B Widelitz  Cheng-Ming Chuong Chi Zhang  Jun Yin  Yongchun Zuo*, Comparative genomics and transcriptomics of Chrysolophus provide insights into the evolution of complex plumage colouration. GigaScience, 2018, giy113, https://doi.org/10.1093/gigascience/giy113 . (2017 IF: 7.267).  
(54).  Wang SY, Huo HY, Su DQ,  Lu QZ, Chen XW, Yang L, Zuo YC*, Lv YL, Characterize the difference between TMPRSS2-ERG and non-TMPRSS2-ERG fusion patients by clinical and biological characteristics in prostate cancer, Gene, 2018 679:186-194. (2017 IF: 2.498). 
(53).  Lei Yang,  Shiyuan Wang,  Qi Zhang,  Yi Pan,  Yingli Lv,  Xiaowen Chen,  Yongchun Zuo*  and  Dapeng Hao, Clinical significance of immune microenvironment in ovarian cancer patients. Mol. Omics, 2018, DOI: 10.1039/C8MO00128F. (2016 IF: 2.781). 
(52).  Luqiang Zhang, Qianzhong Li, Wen Jin, Yongchun Zuo, Shuchun Guo. Genome-wide analysis of H3K36me3 and its regulations to cancer-related genes expression in human cell lines. 2018 Biosystems DOI: 10.1016/j.biosystems.2018.07.004. (2017 IF: 1.619). 
(51).  Qi Zhang, Shiyuan Wang, Yi Pan, Dongqing Su, Qianzi Lu, Yongchun Zuo*, Lei Yang*, Characterization of proteins in different subcellular localizations for Escherichia coli K12, Genomics, 2018, https://doi.org/10.1016/j.ygeno.2018.07.008. (2017 IF: 2.910). 
(50).  Liu DY, Li GP, Zuo YC*, Function determinants of TET proteins: the arrangements of sequence motifs with specific codes. Brief Bioinform. 2018, bby053, https://doi.org/10.1093/bib/bby053. (2017 IF: 6.302) .
(49)  Mengye Lu, Shuai Liu, Arun Kumarsangaiah, Yunpeng Zhou, Zheng Pan, Zuo YC, Nucleosome Positioning with Fractal Entropy Increment of Diversity in Telemedicine. 2018,  IEEE Access, DOI 10.1109/ACCESS.2017.2779850. (2017 IF: 3.557)
2017:
(48)   Zuo YC*, Su GH, Cheng L, Liu K, Feng Y, Wei ZY, Bai CL, Cao GF, Li GP*, Coexpression analysis identifies nuclear reprogramming barriers of somatic cell nuclear transfer embryos, Oncotarget, 2017, 8(39)  65847-65859  (2016 IF: 5.168). 
(47)  Huo HY, Li T, Wang SY,  Lv YL, Zuo YC*, Yang L*, Prediction of presynaptic and postsynaptic neurotoxins by using Pseudo amino acid composition and motif features, Scientific Reports,  7: 5827  (2016 IF: 4.259). 
(46)  Yang L, Wang SY, Zhou M, Chen XW, Jiang W*, Zuo YC*, lv YL*, Molecular classification of prostate adenocarcinoma by the integrated somatic mutation profiles and molecular network. Scientific Reports, 2017, 7(1):738. (2016 IF: 4.259). 
(45)  Guo SC^# , Zuo YC^#, Zhang YF, Wu CY, Su WX, Jin W, Yu HF,  An YL,  Li QZ*. Large-scale transcriptome comparison of sunflower genes responsive to Verticillium dahliae. BMC Genomics.  2017. 18(1):42  (2015 IF: 3.867).
(44)  Zuo YC*, Li Y, Chen YL, Li GP, Yan ZH, Yang L. PseKRAAC: A flexible web server for generating pseudo K-tuple reduced amino acids composition. ,Bioinformatics.  2017, 33(1):122-124 (2016 IF:7.307).ESI 1%高被引. 
(43)  Che D, Wang Y, Bai W, Li L, Liu G, Zhang L, Zuo YC, Tao S, Hua J, Liao M*. Dynamic and modular gene regulatory networks drive the development of gametogenesis. Brief Bioinform. 2017 18(4):712-721. (2015 IF: 5.134)
2016:
(42)  Zuo YC*, Su GH, Wang SS, Yang L, Liao MZ, Wei ZY, Bai CL, Li GP*. Exploring timing activation of functional pathway based on differential co-expression analysis in preimplantation embryogenesis, Oncotarget, 2016 7(45): 74120-74131. (2014 IF: 6.359).
(41) Yang L, Wang SY,  Zhou M,  Chen XW, Zuo YC*, Lv YL*. Characterize the relationship between essential and TATA-containing genes for S. cerevisiae by network topologies in the perturbation sensitivity network. Genomics, 2016 108(3-4) 177-183. (2015 IF: 2.386).
(40 ) Yang L, Wang SY, Zhou M, Chen XW, Zuo YC, Lv YL*. Characterization of BioPlex network by topological properties. J Theor Biol.  2016 409:148-154. (2015 IF: 2.049). 
(39)  Su WX, Li QZ*, Zhang LQ, Fan GL, Wu CY, Yan ZH, Zuo YC. Gene expression classification using epigenetic features and DNA sequence composition in the human embryonic stem cell line H1. Gene. 2016, 592(1):227–234 (2015 IF: 2.319)
(38)  Zhang L, Xuan H, Zuo YC, Xu G, Wang P, Song Y, Zhang SH*. Topological characteristics of target genes regulated by abiotic-stress-responsible miRNAs in a rice interactome network. Funct Integr Genomics. 2016 16(3):243-51. (2015 IF: 2.265 )
(37)  Jia X, Sun C, Zuo YC, Li G, Li G, Ren L, Chen G. Integrating transcriptomics and metabolomics to characterise the response of Astragalus membranaceus Bge. var. mongolicus (Bge.) to progressive drought stress. BMC Genomics. 2016 17:188. (2014 IF: 3.986)
(36)  Yang L, Wang S, Zhou M, Chen X, Zuo YC, Sun D, Lv Y.Comparative analysis  of housekeepingand tissue-selective genes in Human based on network topologies  andbiological properties. Molecular Genetics and Genomics,  2016 291(3):1227-41 (2014 IF: 2.728)
(35)  Su WX, Li QZ*, Zuo YC, Zhang LQ. Association analysis between the  distributions of histone modifications and gene expression in the human  embryonic stem cell. Gene, 2016  575(1):90-100. (2014 IF: 2.019)
2015:
(34) Zuo YC, Lv Y, Wei Z, Yang L, Li G, Fan G. iDPF-PseRAAAC : A  web-server for identifying the defensin peptide family and subfamily using  pseudo reduced amino acid alphabet composition. PLOS ONE, 2015 Dec 29;10(12):e0145541. (2014 IF: 3.234).
 (33)  Tai, DP, Liu, PX, Gao, J,  Jin, MZ, Xu, T, Zuo, YC, Liang, H, Liu, DJ*. Generation of  Arbas Cashmere Goat Induced Pluripotent Stem Cells Through Fibroblast  Reprogramming. Cellular Reprogramming, 2015 17(4): 297-305. (2014 IF: 1.788).  
 (32)  Yang L, Hao D, Wang J, Xing X, Lv Y, Zuo YC*, Jiang W*. Characterization of  proteins in S. cerevisiae with subcellular localizations Molecular  BioSystems, 2015, 11(5),  1360-9. (2014 IF: 3.210).
 (31)  Zuo YC*, Su WX, Zhang SH, Wang SS, Wu CY, Yang L, Li GP.  Discrimination of membrane transporter protein types using K-nearest neighbor  method derived from similarity distance of total diversity measure.  Molecular BioSystems,2015 11(3):950-7. (2014 IF: 3.210).  
 (30) Yang L, Hao D, Lv Y, Zuo YC*, Jiang W*. Genome-wide characterization of essential,  toxicity-modulating and nophenotype genes in S. cerevisiae,  GENE, 2015 559(1):1-8. (2014 IF: 2.019)
2014:
(29) Zuo YC, Gao Y, Su G, Bai C, Wei Z, Liu K, Li Q, Bou S1, Li GP.*  Irregular transcriptome reprogramming probably causes thec developmental failure  of embryos produced by interspecies somatic cell nuclear transfer between the  Przewalski's gazelle and the bovine. BMC Genomics, 2014,  15:1113. (2013 IF: 4.041). 
 (28) Yang L, Wang J, Lv Y, Hao D, Zuo YC, Li X, Jiang W. Characterization of  TATA-containing genes and TATA-less genes in S. cerevisiae by network topologies  and biological properties. Genomics. 2014 104(6B):562-71. (2013 IF: 2.793).  
 (27)  Yang L, Wang J, Wang H, Lv Y, Zuo YC, Li X, Jiang W. Analysis and identification  of essential genes in humans using topological properties and biological  information Gene. 2014, 349:82-91. (2013 IF: 2.082).  
 (26) Fan GL, Liu YL, Zuo YC*, Mei HX, Rang Y, Hou BY, Zhao Y. acACS: Improving  the Prediction Accuracy of Protein Subcellular Locations and Protein  Classification by Incorporating the Average Chemical Shifts Composition.  The Scientific World Journal. 2014:864135, 1-9. (2013 IF: 1.73).  
 (25)  Zuo YC*, Peng Y, Liu L, Chen W, Yang L, Fan GL. Predicting peroxidase subcellular location by  hybridizing different descriptors of Chou' pseudo amino acid patterns.  Anal Biochem. 2014 458:14-9. (2013 IF: 2.305). 
 (24) Yang L, Lv Y, Li T, Zuo YC*, Jiang W.*. Human proteins  characterization with subcellular localizations. J Theor Biol.  2014 358C:61-73. (2013 IF: 2.303). 
 (23) Yang L, Wang J, Wang H, Lv Y, Zuo YC*, Jiang W. Characterization of  essential genes by topological properties in the perturbation sensitivity  network. Biochem Biophys Res Commun. 2014 448(4):473-9. (2008 IF: 2.281).  
 (22)  Zuo YC*, Zhang P, Liu L, Li T, Peng Y, Li G, Li QZ. Sequence-specific  flexibility organization of splicing flanking sequence and prediction of splice  sites in the human genome. Chromosome Research ,2014  22(3):321-34. (2013 IF: 2.688). 
 (21)  Huang X, Han X, Uyunbilig B, Zhang M, Duo S, Zuo YC, Zhao Y, Yun T, Tai D, Wang C, Li J, Li XL*, Li RF*. Establishment of Bovine Trophoblast Stem-Like Cells from In Vitro-Produced  Blastocyst-Stage Embryos Using Two Inhibitors. Stem Cells Dev.  2014 23(13):1501-14. (2013 IF: 4.202). 
 (20) Feng P, Lin H, Chen W, Zuo YC, Predicting the types of J-proteins using  clustered amino acids. BioMed Research International,2014,  935719. (2014 IF: 1.579). 
 (19)  Yang L, Wang J, Wang H, Lv Y, Zuo YC*, Jiang W. Analysis and identification of  toxin targets by topological properties in protein–protein interaction network,  Journal of Theoretical Biologys, 2014 349(2014)82–91. (2013 IF: 2.303)
2013:
(18)  Liu L, Li QZ, Lin H, Zuo YC. The effect of regions flanking  target site on siRNA potency. Genomics 2013 102(4) 215-222. (2012 IF: 3.010).  
 (17)  Fan GL, Li QZ, Zuo YC. Predicting acidic and alkaline enzymes by incorporating the  average chemical shift and gene ontology informations into the general form of  Chou's PseAAC. Process Biochemistry 48 (2013) 1048–1053. (2012 IF: 2.414).  
 (16) Li T, Li QZ, Liu S, Fan GL, Zuo YC, Peng Y. PreDNA: accurate prediction of  DNA-binding sites in proteins by integrating sequence and geometric structure  information, Bioinformatics, 2013,  29(6):678-85. (2012 IF: 5.323).
 (15)  Uyunbilig B, Gu T, He  ZY, Wu X, Li GP,Li QZ, Ding XY, Zuo  YC*, Wang X*, Analysis of Transcription  Factors Regulated Stem Cell Differentiation by ChIP-Seq. Chinese Journal  of Cell Biology 2013, 35(6): 870–879  
 (14) Zuo YC*, Chen W, Fan GL, Li QZ. A  similarity distance of diversity measure for discriminating mesophilic and  thermophilic proteins. Amino Acids. 2013，44(2):573-80. (2012 IF: 3.914)
2012:
(13) Zuo YC*, Li QZ. The DNA geometric flexibility of promoter in  model organism genomes, Procedia 2012  (2011)2732–2737. (EI, ISTP).
 (12) Chen W, Lin H, Feng PM, Ding  C, Zuo YC, Chou KC. iNuc-PhysChem: A Sequence-Based Predictor  for Identifying Nucleosomes via Physicochemical Properties. PLoS  One. 2012;7(10):e47843. (2011 IF: 4.092) ESI 1%高被引.
2011:
(11)  Zuo YC, Li QZ*. Identification of TATA and TATA-less promoters  in plant genomes by integrating diversity measure, GC-Skew and DNA geometric  flexibility. 2011 Genomics. 97(3):  112-120. (2010 IF: 3.327).
 (10)  Zuo YC, Li QZ*. The DNA Geometric Flexibility Property around the Transcription  Initiation in Model Organism Genomes. 2011 International Conference on  Bioscience, Biochemistry and Bioinformatics 2011,  314-318.(EI, ISTP).
 (9)  Zuo YC, Li QZ*. The positional distribution of TATA-box and TC-element in the transcription  start region. 2011 International Biophysics Congress (17th IBC)  2011, 588-589. (EI, ISTP).
2010 以前:
 (8)  Zuo YC, Li QZ*. The hidden physical codes for modulating the prokaryotic transcription initiation. 2010 Physica A 2010  389(19) 4217–4223. (2009 IF: 1.562).
 (7)  Zuo YC, Li QZ*. Using K-minimum increment of diversity to predict secretory  proteins of malaria parasite based on groupings of amino acids. 2010,  Amino Acids. 2010(3) 38:859–867. (2008 IF: 4.132).
 (6)   Zuo YC, Li QZ*. . Using reduced amino acid composition to predict  defensin family and subfamily: Integrating similarity measure and structural  alphabet. 2009, Peptides. 30(10)  1788–1793. (2008 IF: 2.565).
 (5)   Zuo YC, Li QZ*. Analysis of plant TATA and TATA-less promoters by using sequence  and structure features. 2009，Progress in Biochemistry and  Biophysics. 36(7): 863-871. (2008 IF: 0.211).
 (4)   Zuo YC, Li QZ*. Predicting plant Pol-Ⅱ promoter based on  subsequence increment of overlap content diversity. 2009 2nd  International Conference On Biomedical Engineering and Informatics, Vol  (3) 1494-1498. (EI, ISTP) .
 (3)  Zuo YC, Li QZ*. Using Six Physical Structural Parameters to Describe the Plant  Transcription Initiation. 2009 Proceedings of the International  Conference of Genomics, Vol (1) 91-92. (EI, ISTP) .
 (2) Yang L, Li QZ*, Zuo YC. Prediction of human  transcription factor binding sites by using an improved position correlation  scoring function. Journal of Inner Mongolia University, 2009,  40(1):60-67.
 (1) Yang L, Li QZ*, Zuo YC. Prediction of presynaptic and postsynaptic  neurotoxins using hybrid approach and pseudo amino acid composition. 2009  2nd International Conference On Biomedical Engineering and  Informatics, Vol (3) 1504-1507. (EI, ISTP).