莫日根教授简介
文章来源:      发布时间:2018-03-13     点击次数:

  莫日根(Morigen),2005年毕业于挪威奥斯陆大学医学院分子生物学专业,获博士学位。之后在挪威肿瘤医院癌症研究所做博士后研究。2009年10月回国任内蒙古大学生命科学学院生物化学与分子生物学教授、博士生导师。

现任生命科学学院院长、内蒙古自治区细胞分子调控重点实验室主任、内蒙古自治区细胞分子工程技术研究中心主任、省部共建草原家畜生殖调控与繁育国家重点实验室副主任。兼任内蒙古遗传学会副理事长、中国遗传学会微生物专业委员会委员、中国细胞生物学会理事、《高校生物学教学研究(电子版)》编委、《中国细胞生物学学报》编委、《中国生物化学与分子生物学报》编委。

Email:morigenm@life.imu.edu.cn

一、研究领域和兴趣: 
    

       1. 细菌DNA复制、细胞周期及环境适应分子机制与耐药性。主要以大肠杆菌为模式生物,研究DNA复制与基因组稳定、细胞周期、代谢和基因表达调控分子机制,揭示细胞环境适应性和耐药性分子机理。
    
       2. 癌细胞DNA复制与基因组稳定性。

Research interests:     

       1. The Escherichia coli DNA replication, cell cycle and environmental adaptation.     
       2. DNA replication in cancer cells.

二、相关学术论文:

 

1. Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen*

The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting

 G1-S-phase transition and inducing apoptosis, Oncotarget, doi:10.18632/oncotarget.16872, 2017.

2. Yao Y, Fan L, Shi Y, Odsbu I, Morigen*

A spatial control for correct timing of gene expression during the Escherichia coli cell cycle, Genes,

8(1), 1, doi:10.3390/genes8010001, 2017.

3. Wurihan, Wunier, Li H, Fan L, Morigen*

 Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli,

Gent Mol Res, 15 (3): gmr.15 038407, 2016.

4. Yao Y, Wunier, Morigen*

Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli, Gent Mol Res,

14(4):16888-16895, 2015.

5. Fan L, Yan H, Pellegrin S, Morigen*, H Mellor

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction, Neurosci Lett,

590(-):178-183, 2015.

6. Dong Q, Dong A, Morigen*

Evaluation of novel antibacterial N-halamine nanoparticles prodrugs towards susceptibility of Escherichia coli

induced by DksA protein, Molecules, 21; 20(4):7292-308, 2015.

7. Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L, Morigen*

AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle, PLoS ONE, 9(3):e92229, 2014.

8. Morigen, Flatten I, K Skarstad

The Escherichia coli datA site promotes proper regulation of cell division, SGM-Microbiol, 160(4):703-710, 2014.

9. Fan L, Morigen*

Rho and Ras GTPases in semaphorin-mediated neuronal development, Adv Biosci Biotech, 4:136-142, 2013.

10. Johnsen L, Flatten I, Morigen, Dalhus B, Bjoras M, Waldminghaus T, K Skarstad

The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of Replication,

Mol Microbiol , 79(2):433-446, 2011.

11.Weatherspoon-Griffin N, Zhao G, Kong W, Kong Y, Morigen, Andrews-Polymenis H, McClelland M, Y Shi

   The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer

   bacterial resistance to antimicrobial peptide, J Biol Chem, 286(7):5529-39, 2011.

12. Morigen, Odsbu I, K Skarstad

Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing

Escherichia coli, Genes Cells, 14(5):643-657, 2009.

13. Wang J, Morigen

BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding

parameters for yeast transcription factors, BMC Bioinformatics, 10:345, 2009.

14. Odsbu I., Morigen, K Skarstad

A reduction in ribonucleotide reductase activity slows down the chromo some replication fork but does not

change its localization, PLoS ONE, 4(10):e7617, 2009.

15. Flatten I, Morigen, K Skarstad

DnaA protein interacts with RNA polymerase and protects it from the effect of rifampicin, Mol Microbiol,

71(4):1018-1030, 2009.

16. Bach T, Morigen, K Skarstad

The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of

hemimethylated DNA, J Mol Biol, 384(5):1076-85, 2008.

17. Morigen, Molina F, K Skarstad

Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication,

J Bacteriol, 187(12):3913-20, 2005.

18. Morigen, Lobner-Olesen A, K Skarstad

Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilization of replication forks,

delayed replication initiation and delayed cell division, Mol Microbiol, 50:349-362, 2003.

19. Morigen, Boye E, Skarstad K, A Lobner-Olesen

Regulation of   chromosomal   replication by DnaA protein availability in Escherichia coli: effects of the datA

region, Biochim Biophys Acta, 1521: 73-80, 2001.

20. Weigel C, Messer W, Preiss S, Welzeck M, Morigen, E Boye

The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome

and a minichromosome, Mol Microbiol, 40(2): 498-507, 2001.

 

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