莫日根（Morigen），2005年毕业于挪威奥斯陆大学医学院分子生物学专业，获博士学位。之后在挪威肿瘤医院癌症研究所做博士后研究。2009年10月回国任内蒙古大学生命科学学院生物化学与分子生物学教授、博士生导师。兼任内蒙古遗传学会副理事长、中国遗传学会微生物专业委员会委员、中国细胞生物学会理事、《高校生物学教学研究（电子版）》编委、《中国细胞生物学学报》编委、《中国生物化学与分子生物学报》编委。
Email：morigenm@life.imu.edu.cn
一、研究领域和兴趣：
1. 细菌DNA复制、细胞周期及环境适应分子机制与耐药性。主要以大肠杆菌为模式生物，研究DNA复制与基因组稳定、细胞周期、代谢和基因表达调控分子机制，揭示细胞环境适应性和耐药性分子机理。
2. 癌细胞DNA复制与基因组稳定性。研究癌细胞DNA复制与基因组稳定性以及肿瘤发生发展和早期诊断。
Research interests:
1. The Escherichia coli DNA replication, cell cycle and environmental adaptation.
2. DNA replication in cancer cells.
二、相关学术论文：
1. Fan L, Cao X, Yan H, Wang Q, Tian X, Zhang L, He X, Borjihan G, Morigen*
The synthetic antihyperlipidemic drug potassium piperate selectively kills breast cancer cells through inhibiting
G1-S-phase transition and inducing apoptosis, Oncotarget, doi:10.18632/oncotarget.16872, 2017.
2. Yao Y, Fan L, Shi Y, Odsbu I, Morigen*
A spatial control for correct timing of gene expression during the Escherichia coli cell cycle, Genes,
8(1), 1, doi:10.3390/genes8010001, 2017.
3. Wurihan, Wunier, Li H, Fan L, Morigen*
Trans-translation ensures timely initiation of DNA replication and DnaA synthesis in Escherichia coli,
Gent Mol Res, 15 (3): gmr.15 038407, 2016.
4. Yao Y, Wunier, Morigen*
Absence of the BaeR protein leads to the early initiation of DNA replication in Escherichia coli, Gent Mol Res,
14(4):16888-16895, 2015.
5. Fan L, Yan H, Pellegrin S, Morigen*, H Mellor
The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction, Neurosci Lett,
590(-):178-183, 2015.
6. Dong Q, Dong A, Morigen*
Evaluation of novel antibacterial N-halamine nanoparticles prodrugs towards susceptibility of Escherichia coli
induced by DksA protein, Molecules, 21; 20(4):7292-308, 2015.
7. Liu F, Qimuge, Hao J, Yan H, Bach T, Fan L, Morigen*
AspC-mediated aspartate metabolism coordinates the Escherichia coli cell cycle, PLoS ONE, 9(3):e92229, 2014.
8. Morigen, Flatten I, K Skarstad
The Escherichia coli datA site promotes proper regulation of cell division, SGM-Microbiol, 160(4):703-710, 2014.
9. Fan L, Morigen*
Rho and Ras GTPases in semaphorin-mediated neuronal development, Adv Biosci Biotech, 4:136-142, 2013.
10. Johnsen L, Flatten I, Morigen, Dalhus B, Bjoras M, Waldminghaus T, K Skarstad
The G157C mutation in the Escherichia coli sliding clamp specifically affects initiation of Replication,
Mol Microbiol , 79(2):433-446, 2011.
11.Weatherspoon-Griffin N, Zhao G, Kong W, Kong Y, Morigen, Andrews-Polymenis H, McClelland M, Y Shi
The CpxR/CpxA two-component system up-regulates two Tat-dependent peptidoglycan amidases to confer
bacterial resistance to antimicrobial peptide, J Biol Chem, 286(7):5529-39, 2011.
12. Morigen, Odsbu I, K Skarstad
Growth rate dependent numbers of SeqA structures organize the multiple replication forks in rapidly growing
Escherichia coli, Genes Cells, 14(5):643-657, 2009.
13. Wang J, Morigen
BayesPI--a new model to study protein-DNA interaction: a case study of condition-specific protein binding
parameters for yeast transcription factors, BMC Bioinformatics, 10:345, 2009.
14. Odsbu I., Morigen, K Skarstad
A reduction in ribonucleotide reductase activity slows down the chromo some replication fork but does not
change its localization, PLoS ONE, 4(10):e7617, 2009.
15. Flatten I, Morigen, K Skarstad
DnaA protein interacts with RNA polymerase and protects it from the effect of rifampicin, Mol Microbiol,
71(4):1018-1030, 2009.
16. Bach T, Morigen, K Skarstad
The initiator protein DnaA contributes to keeping new origins inactivated by promoting the presence of
hemimethylated DNA, J Mol Biol, 384(5):1076-85, 2008.
17. Morigen, Molina F, K Skarstad
Deletion of the datA site does not affect once-per-cell-cycle timing but induces rifampin-resistant replication,
J Bacteriol, 187(12):3913-20, 2005.
18. Morigen, Lobner-Olesen A, K Skarstad
Titration of the Escherichia coli DnaA protein to excess datA sites causes destabilization of replication forks,
delayed replication initiation and delayed cell division, Mol Microbiol, 50:349-362, 2003.
19. Morigen, Boye E, Skarstad K, A Lobner-Olesen
Regulation of chromosomal replication by DnaA protein availability in Escherichia coli: effects of the datA
region, Biochim Biophys Acta, 1521: 73-80, 2001.
20. Weigel C, Messer W, Preiss S, Welzeck M, Morigen, E Boye
The sequence requirements for a functional Escherichia coli replication origin are different for the chromosome
and a minichromosome, Mol Microbiol, 40(2): 498-507, 2001.
